Your partner in drug discovery in inflammation and infection

Welcome to Artimmune - Your trusted partner in drug discovery for inflammation and infection. With a focus on scientific expertise, collaboration, and reliability, we are dedicated to advancing research in immunology and inflammation. As the world faces the challenges of COVID-19, Artimmune is committed to providing optimized research solutions. Our murine model of cytokine storm aids in the investigation of new drug candidates to combat COVID-19. Explore our preclinical CRO services and benefit from our extensive experience in lung diseases and immunology. Contact us to drive your research projects forward.



Darby M, Roberts LB, Mackowiak C, Chetty A, Tinelli S, Schnoeller C, Quesniaux V, Berrard S, Togbe D, Selkirk ME, Ryffel B, Horsnell WGC. ILC3-derived acetylcholine promotes protease-driven allergic lung pathology. J Allergy Clin Immunol. 2020 Dec 19:S0091-6749(20)31586-4. doi: 10.1016/j.jaci.2020.10.038. Online ahead of print. PMID: 33461747

Reverchon F, de Concini V, Larrigaldie V, Benmerzoug S, Briault S, Togbé D, Ryffel B, Quesniaux VFJ, Menuet A. Hippocampal interleukin-33 mediates neuroinflammation-induced cognitive impairments. J Neuroinflammation. 2020 Sep 11;17(1):268. doi: 10.1186/s12974-020-01939-6. PMID: 32917228

Wiegman CH, Li F, Ryffel B, Togbe D, Chung KF. Oxidative Stress in Ozone-Induced Chronic Lung Inflammation and Emphysema: A Facet of Chronic Obstructive Pulmonary Disease. Front Immunol. 2020 Sep 2;11:1957. doi: 10.3389/fimmu.2020.01957. eCollection 2020. PMID: 32983127

Wollin L, Togbe D, Ryffel B. Effects of Nintedanib in an Animal Model of Liver Fibrosis. Biomed Res Int. 2020 Mar 31;2020:3867198. doi: 10.1155/2020/3867198. eCollection 2020. PMID: 32337244

Floris I, Chenuet P, Togbe D, Volteau C, Lejeune B. Potential Role of the Micro-Immunotherapy Medicine 2LALERG in the Treatment of Pollen-Induced Allergic Inflammation. Dose Response. 2020 Mar 24;18(1):1559325820914092. doi: 10.1177/1559325820914092. eCollection 2020 Jan-Mar. PMID: 32269504

Michaudel C, Bataille F, Maillet I, Fauconnier L, Colas C, Sokol H, Straube M, Couturier-Maillard A, Dumoutier L, van Snick J, Quesniaux VF, Togbe D, Ryffel B. Ozone-Induced Aryl Hydrocarbon Receptor Activation Controls Lung Inflammation via Interleukin-22 Modulation. Front Immunol. 2020 Feb 25;11:144. doi: 10.3389/fimmu.2020.00144. eCollection 2020. PMID: 32161582


Gebhardt A, Bergant V, Schnepf D, Moser M, Meiler A, Togbe D, Mackowiak C, Reinert LS, Paludan SR, Ryffel B, Stukalov A, Staeheli P, Pichlmair A. The alternative cap-binding complex is required for antiviral defense in vivo. PLoS Pathog. 2019 Dec 19;15(12):e1008155. doi: 10.1371/journal.ppat.1008155. eCollection 2019 Dec. PMID: 31856218.

Sokolowska M, Quesniaux VFJ, Akdis CA, Chung KF, Ryffel B, Togbe D. Acute Respiratory Barrier Disruption by Ozone Exposure in Mice. Front Immunol. 2019 Sep 13;10:2169. doi: 10.3389/fimmu.2019.02169. eCollection 2019. PMID: 31608051

1: Benmerzoug S, Bounab B, Rose S, Gosset D, Biet F, Cochard T, Xavier A, Rouxel N, Fauconnier L, Horsnell WGC, Ryffel B, Togbe D, Quesniaux VFJ. Sterile Lung Inflammation Induced by Silica Exacerbates Mycobacterium tuberculosis Infection via STING-Dependent Type 2 Immunity. Cell Rep. 2019 May 28;27(9):2649-2664.e5. doi: 10.1016/j.celrep.2019.04.110. PubMed PMID: 31141689.


Benmerzoug S, Rose S, Bounab B, Gosset D, Duneau L, Chenuet P, Mollet L, Le Bert M, Lambers C, Geleff S, Roth M, Fauconnier L, Sedda D, Carvalho C, Perche O, Laurenceau D, Ryffel B, Apetoh L, Kiziltunc A, Uslu H, Albez FS, Akgun M, Togbe D, Quesniaux VFJ. STING-dependent sensing of self-DNA drives silica-induced lung inflammation. Nat Commun. 2018 Dec 6;9(1):5226. doi: 10.1038/s41467-018-07425-1. PubMed PMID: 30523277; PubMed Central PMCID: PMC6283886.

Dalloul Z, Chenuet P, Dalloul I, Boyer F, Aldigier JC, Laffleur B, El Makhour Y, Ryffel B, Quesniaux VFJ, Togbé D, Mergny JL, Cook-Moreau J, Cogné M. G-quadruplex DNA targeting alters class-switch recombination in B cells and attenuates allergic inflammation. J Allergy Clin Immunol. 2018 Oct;142(4):1352-1355. doi: 10.1016/j.jaci.2018.06.011. Epub 2018 Jun 20. PubMed PMID: 29935221.

Michaudel C, Mackowiak C, Maillet I, Fauconnier L, Akdis CA, Sokolowska M, Dreher A, Tan HT, Quesniaux VF, Ryffel B, Togbe D. Ozone exposure induces respiratory barrier biphasic injury and inflammation controlled by IL-33. J Allergy Clin Immunol. 2018 Sep;142(3):942-958. doi: 10.1016/j.jaci.2017.11.044. Epub 2018 Jan 10. PubMed PMID: 29331644.

Palomo J, Quesniaux VFJ, Togbe D, Reverchon F, Ryffel B. Unravelling the roles of innate lymphoid cells in cerebral malaria pathogenesis. Parasite Immunol. 2018 Feb;40(2). doi: 10.1111/pim.12502. Review. PubMed PMID: 29117626.


Chenuet P, Fauconnier L, Madouri F, Marchiol T, Rouxel N, Ledru A, Mauny P, Lory R, Uttenhove C, van Snick J, Iwakura Y, di Padova F, Quesniaux V, Togbe D, Ryffel B. Neutralization of either IL-17A or IL-17F is sufficient to inhibit house dust mite induced allergic asthma in mice. Clin Sci (Lond). 2017 Oct 12;131(20):2533-2548. doi: 10.1042/CS20171034. Print 2017 Oct 15. PubMed PMID: 29026003.

Li C, Maillet I, Mackowiak C, Viala C, Di Padova F, Li M, Togbe D, Quesniaux V, Lai Y, Ryffel B. Experimental atopic dermatitis depends on IL-33R signaling via MyD88 in dendritic cells. Cell Death Dis. 2017 Apr 6;8(4):e2735. doi: 10.1038/cddis.2017.90. PubMed PMID: 28383552; PubMed Central PMCID: PMC5477596.

Madouri F, Chenuet P, Beuraud C, Fauconnier L, Marchiol T, Rouxel N, Ledru A, Gallerand M, Lombardi V, Mascarell L, Marquant Q, Apetoh L, Erard F, Le Bert M, Trovero F, Quesniaux VFJ, Ryffel B, Togbe D. Protein kinase Cθ controls type 2 innate lymphoid cell and T(H)2 responses to house dust mite allergen. J Allergy Clin Immunol. 2017 May;139(5):1650-1666. doi: 10.1016/j.jaci.2016.08.044. Epub 2016 Oct 14. PubMed PMID: 27746240.

Mascarell L, Airouche S, Berjont N, Gary C, Gueguen C, Fourcade G, Bellier B, Togbe D, Ryffel B, Klatzmann D, Baron-Bodo V, Moingeon P. The regulatory dendritic cell marker C1q is a potent inhibitor of allergic inflammation. Mucosal Immunol. 2017 May;10(3):695-704. doi: 10.1038/mi.2016.87. Epub 2016 Oct 12. PubMed PMID: 27731323.


Cochez PM, Michiels C, Hendrickx E, Van Belle AB, Lemaire MM, Dauguet N, Warnier G, de Heusch M, Togbe D, Ryffel B, Coulie PG, Renauld JC, Dumoutier L. AhR modulates the IL-22-producing cell proliferation/recruitment in imiquimod-induced psoriasis mouse model. Eur J Immunol. 2016 Jun;46(6):1449-59. doi: 10.1002/eji.201546070. PubMed PMID: 27000947.


Rabeony H, Pohin M, Vasseur P, Petit-Paris I, Jégou JF, Favot L, Frouin E, Boutet MA, Blanchard F, Togbe D, Ryffel B, Bernard FX, Lecron JC, Morel F. IMQ-induced skin inflammation in mice is dependent on IL-1R1 and MyD88 signaling but independent of the NLRP3 inflammasome. Eur J Immunol. 2015 45:2847-57. PMID: 26147228

Bruchard M, Rebé C, Derangère V, Togbe D, Ryffel B, Boidot R, Humblin E, Hamman A, Chalmin F, Berger H, Chevriaux A, Limagne E, Apetoh L, Végran F, Ghiringhelli F. The receptor NLRP3 is a transcriptional regulator of TH2 differentiation. Nat Immunol. 2015 16: 859-70. PMID: 26098997

Madouri F, Guillou N, Fauconnier L, Marchiol T, Rouxel N, Chenuet P, Ledru A, Apetoh L, Ghiringhelli F, Chamaillard M, Zheng SG, Trovero F, Quesniaux VF, Ryffel B, Togbe D. Caspase-1 activation by NLRP3 inflammasome dampens IL-33-dependent house dust mite-induced allergic lung inflammation. J Mol Cell Biol. 2015; 7: 351-65. PMID:25714839.


Palomo J, Marchiol T, Piotet J, Fauconnier L, Robinet M, Reverchon F, Le Bert M, Togbe D, Buijs-Offerman R, Stolarczyk M, Quesniaux VF, Scholte BJ, Ryffel B. Role of IL-1ß in experimental cystic fibrosis upon P. aeruginosa infection. PLoS One. 2014;9 (12):e114884. PMID:25500839


Palomo J, Fauconnier M, Coquard L, Gilles M, Meme S, Szeremeta F, Fick L, Franetich JF, Jacobs M, Togbe D, Beloeil JC, Mazier D, Ryffel B, Quesniaux VF. Type I interferons contribute to experimental cerebral malaria development in response to sporozoite or blood-stage Plasmodium berghei ANKA. Eur J Immunol. 2013; 43: 2683-95. PMID:23780878

Togbe D, Fauconnier L, Madouri F, Marchiol T, Chenuet P, Rouxel N, Ledru A, Erard F, Quesniaux V, Ryffel B. Thymic Stromal Lymphopoietin Enhances Th2/Th22 and Reduces IL-17A in Protease-Allergen-Induced Airways Inflammation. ISRN Allergy. 2013:971036. PMID: 23738146

Roversi P, Ryffel B, Togbe D, Maillet I, Teixeira M, Ahmat N, Paesen GC, Lissina O, Boland W, Ploss K, Caesar JJ, Leonhartsberger S, Lea SM, Nunn MA. Bifunctional lipocalin ameliorates murine immune complex-induced acute lung injury. J Biol Chem. 2013; 288:18789-802. PMID: 23625922.


Xu W, Lan Q, Chen M, Chen H, Zhu N, Zhou X, Wang J, Fan H, Yan CS, Kuang JL, Warburton D, Togbe D, Ryffel B, Zheng SG, Shi W. Adoptive transfer of induced-Treg cells effectively attenuates murine airway allergic inflammation. PLoS One. 2012;7(7):e40314. PMID:22792275

Jiang HR, Milovanovic M, Allan D, Niedbala W, Besnard AG, Fukada SY, Alves-Filho JC, Togbe D, Goodyear CS, Linington C, Xu D, Lukic ML, Liew FY. IL-33 attenuates EAE by suppressing IL-17 and IFN-γ production and inducing alternatively activated macrophages. Eur J Immunol. 2012;42:1804-14. PMID:22585447

Besnard AG, Togbe D, Couillin I, Tan Z, Zheng SG, Erard F, Le Bert M, Quesniaux V, Ryffel B. Inflammasome-IL-1-Th17 response in allergic lung inflammation. J Mol Cell Biol. 2012; 4:3-10. PMID:22147847