in vivo services >> CNS inflammation
Acute experimental encephalomyelitis (MS model)
MOG immunized young female BL6 mice develop progressive neurological signs with paresis and paralysis and loss of body weight. Dexamethasone inhibits efficiently the automimmune disease as is used as a positive control.
Mice are sacrificed on day 24 for cytokine/chemokine production and microscopic analysis: IL-1 and the chemokines CCL2 and CCL5 are significantly increased in the brain homogenates, and a distinct inflammation is found in the spinal cord.
(Jiang et al, 2012)